Bremelanotide: A Treatment for Hypoactive Sexual Desire

In the Phase 2b clinical study, women were allowed to use DARE to PLAY during oral sex, and it was well tolerated with no significant safety concerns.

• A healthy, balanced diet supports overall health, including hormonal balance.
• Regular physical exercise improves blood circulation, mood, and body image.
• Adequate sleep is crucial for regulating hormones that influence sexual desire.
• Stress management techniques (yoga, meditation) can reduce a major libido killer.
• Reducing alcohol consumption can improve sexual response and overall health.
• Quitting smoking improves blood flow to sexual organs and overall vitality.
• Open communication with a partner is fundamental for a healthy sexual relationship.

Prior to the Phase 2b clinical study, DARE to PLAY was also tested in a preclinical study to assess its effects on the oral mucosa. These tests showed that daily exposure for 28 days did not cause irritation inside the mouth. The DARE to PLAY formulation does contain a proprietary combination of salts that support the absorption of sildenafil into the tissue. As a result, you may notice a mildly salty taste.

DARE to PLAY can be used in both situations!

If you're tired of uncertain quality and unproven options, you're not alone.

Slowly squeeze out a length of cream about 2 ½ inches long for one 2-gram dose. Lying on your back, apply half the cream on and around the clitoris and the area around viagra 100mg the vaginal opening, avoiding areas with hair. Apply the rest of the cream just inside the vagina, rubbing the cream with a curved finger on the front wall of the vagina. Once applied, do not wipe off any of the cream until after sexual activity. In the Phase 2b clinical study, women did not use lubricants because the study was specifically designed to evaluate the impact of DARE to PLAY on the genital arousal response.

Let's do it.

However, there are no concerns about the compatibility of lubricants with the DARE to PLAY formulation. DARE to PLAY has been studied in both pre-and postmenopausal women to evaluate safety, tolerability, and how the drug is absorbed in the body (pharmacokinetics). In these studies, the cream was well tolerated. The Phase 2b clinical study enrolled healthy pre-and perimenopausal women aged 18 to 45 who had a diagnosis of Female Sexual Arousal Disorder (FSAD). Similar to FDA-approved products for Hypoactive Sexual Desire Disorder (HSDD), FSAD trials conducted for FDA review typically focus on either pre-or postmenopausal populations. In the Phase 2b clinical study, about 20% of sexual events were solo, and women reported that these experiences were often more satisfying than partnered events. Partnered events sometimes occurred under less-than-ideal conditions, like limited time or distractions, which can affect pleasure. DARE to PLAY is designed to complement, not replace, other approaches.

It is a pharmacologic option focused on improving genital blood flow and physical responsiveness. Women often benefit most from a multimodal approach.

• DHEA (Prasterone) is a hormonal precursor available as a vaginal insert for dyspareunia.
• ArginMax is an over-the-counter supplement containing L-arginine, ginseng, and ginkgo.
• Zestra is a topical arousal oil marketed to enhance sensation and blood flow.
• Fertility herbal blends often claim to boost libido but lack robust scientific evidence.
• Maca root is a popular Peruvian supplement sometimes used for hormonal balance.
• It's crucial to consult a doctor before using supplements due to potential side effects.
• The MHRA regulates supplements in the UK, but they are not held to drug efficacy standards.

DARE to PLAY is designed to improve physical arousal by increasing genital blood flow. Many women find that enhancing physical responsiveness can also help restore desire and confidence. In the Phase 2b clinical study, women with low desire due to diminished physical arousal sensations experienced improved desire following use of DARE to PLAY. If low desire is influenced by emotional or relationship factors, combining DARE to PLAY with other approaches—like counseling or therapy—may provide the best results.

• Vaginal moisturizers (e.g., Replens) provide long-lasting relief from dryness.
• Vaginal lubricants (e.g., Sylk, YES) reduce friction and discomfort during intercourse.
• Topical estrogen creams (e.g., Vagifem) locally treat vaginal atrophy and dryness.
• Pelvic floor physical therapy can improve muscle tone and blood flow to the pelvis.
• Sex therapy focuses on improving intimacy and communication with a partner.
• Mindfulness and sensate focus exercises can help reduce performance anxiety.
• Devices like the Eros-Clitoral Therapy Device use gentle suction to increase blood flow.

Yes, please see these instructions for how to get a prescription. Anyone who is licensed to write prescriptions can prescribe it—including your primary care provider (PCP), family medicine doctor, OB/GYN, nurse practitioner, physician assistant, or another qualified specialist.

How DARE to PLAY Sildenafil Cream Works

The high salt content inthis cream helps prevent thatstickiness, allowing sildenafil topenetrate deeper into the tissue. Thisunique structure helps the creaminteract with different skin layers,ensuring the drug gets where itneeds to go. May not penetrate into the epithelial tissue When it comes to your body and your health, consistency and safety aren’t optional – they are essential. You deserve a product that has been clinically studied, carefully formulated, and made to the highest safety and quality standards. With DARE to PLAY Sildenafil Cream, you can feel confident in what you’re using – every single time.

Effects on sexual dysfunction

This is the first clinical study of its kind to demonstrate that this specific topical formulation of sildenafil, DARE to PLAY Sildenafil Cream, can support genital blood flow and arousal in women. Offering a non-hormonal option with a faster onset (10–15 minutes) and fewer side effects than oral medications, it represents a significant breakthrough for female sexual health. Daré’s proprietary formulation of Sildenafil Cream was evaluated in the RESPOND Study, the first-ever randomized, double-blind, placebo-controlled clinical trial for a topical treatment targeting Female Sexual Arousal Disorder (FSAD) submitted to the FDA. This Phase 2b trial included 200 premenopausal women experiencing symptoms of FSAD, such as reduced genital sensation and frustration during intimacy. Safety Profile: The side effect profile of DARE to PLAY Sildenafil Cream was similar to placebo (cream without sildenafil added), with no serious safety concerns reported. The DARE Health Hub (powered viagra packaging by Medvantx) is a nationwide pharmacy and telehealth service. Whether you use the DARE Health Hub telehealth offering to get your prescription or get a prescription from your provider, this is where you will order/fill your prescription. This service offers contact-free ordering and discreet delivery directly to your doorstep. Here’s what you can expect depending on your preferred method of obtaining a prescription: Register for an account at the DARE Health Hub. After registering, you will be asked, “Have you seen a provider already?” Select “No” to initiate a telehealth consultation.

You’ll then be asked to: Provide your address informationSign the telehealth consent agreementFill out the telehealth questionnaireVerify your identification (by uploading a photo ID) Verify your identification (by uploading a photo ID) Within approximately 24 hours, your telehealth questionnaire responses will be reviewed by a licensed healthcare provider, and if medically appropriate, you will receive a prescription for DARE to PLAY.

Get on the List

In the Phase 2b clinical study, approximately one-third of the participants were taking an SSRI. An informal analysis compared women on SSRIs with those who were not and found that both groups showed positive trends in improved arousal sensations. Many vaginal products contain ingredients that can weaken condoms, increasing the risk of breakage. DARE to PLAY was tested using ASTM D7661-10, a standardized method that ensures a product is safe to use with condoms. Based on these tests, DARE to PLAY is compatible with all male condoms except those made of polyurethane. You can check the status of your prescription under “My Prescriptions” in the DARE Health Hub.

Real Science. Real Results.

Study Results:Women using DARE to PLAY Sildenafil Cream experienced the following improvements, as measured by clinically validated and FDA-reviewed endpoints: Reduced feelings of sexual distress and interpersonal difficulties resulting from the sexual difficulties In the Phase 2b trial, after 12 weeks, women who used DARE to PLAY Sildenafil Cream reported statistically significant and clinically meaningful improvements in genital arousal sensation (warmth and tingling) compared to those who used placebo cream. On average, Arousal Sensation scores (measured by a patient-reported questionnaire) increased by over 2 points with DARE to PLAY Sildenafil Cream, compared to almost no change with placebo cream. Women who used DARE to PLAY Sildenafil Cream also showed improvement across other key areas of sexual function, including desire and orgasm. Results shown are from a subset of 65 women in a 12-week clinical trial: 33 women who received Sildenafil Cream and 32 who received Placebo Cream. The results were published in the Green Journal (Obstetrics & Gynecology), the official journal of the American College of Obstetricians and Gynecologists (ACOG) and highlighted on ACOG’s podcast The Green Room.

What causes low libido in women?

Clinical trial results were also featured in The Journal of Sexual Medicine, the official journal of the International Society for the Study of Women’s Sexual Health. DARE to PLAY is the only sildenafil cream for women supported by published, peer-reviewed clinical data. It was studied in clinical trials that used clinically validated and FDA-reviewed endpoints to measure results. The cream is designed with a proprietary drug delivery system that helps sildenafil get into the vaginal and viagra gel vulvar tissue, where it can act locally to increase blood flow. Other sildenafil creams on the market haven’t been proven to work–they have not been studied, shown to absorb properly or published in peer-reviewed research, and are often compounded without consistent quality standards. You will be notified in the coming months, via email and text message, when ordering becomes available in your state. Ordering details will be added once available!

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DARE to PLAY stands apart because it’s rigorously developed, science-backed, and held to the highest standards of quality and clinical evidence. Sildenafil (the active ingredient in Viagra®) has a long-established safety profile in men. The topical formulation used in DARE to PLAY is designed to work locally (in the tissues that matter for sexual arousal) while minimizing how much of the drug enters the bloodstream. DARE to PLAY has been evaluated in clinical studies and was well tolerated, with no significant safety concerns reported. The safety findings from the Phase 2b clinical study have been published and are available on the DARE to PLAY website.

About the pre-fulfillment prescription period.

If you experience difficulty with sexual arousal, including a lack of physical response or reduced genital sensitivity during sexual activity, you may benefit from DARE to PLAY. A conversation with a licensed healthcare provider can help determine whether it is appropriate for you. DARE to PLAY contains the same active ingredient as Viagra®, but it’s formulated specifically for women and applied directly where it’s needed. Unlike an oral pill, DARE to PLAY is a topical cream designed to work locally rather than systemically. Apply the cream with your finger 10 to 15 minutes before sexual activity up to once per day. Talk to your healthcare provider about DARE to PLAY.

• Filbanserin can cause dizziness, sleepiness, nausea, and low blood pressure.
• It has serious interactions with alcohol and certain medications like antifungals.
• Bremelanotide side effects include nausea, vomiting, and temporary skin darkening.
• Ospemifene may increase the risk of blood clots and cause hot flashes.
• Testosterone therapy can cause acne, unwanted hair growth, and voice changes.
• Topical estrogen has minimal systemic absorption but can cause local irritation.
• All prescription treatments require a careful risk-benefit analysis with a doctor.

Bring the prescribing guide with you to your appointment.